在过去十年中，发光二极管（LED）几乎在每个应用中都取代了常见的灯泡，从智能手机中的手电筒到汽车前灯。照亮夜间街道需要LED发出光谱，被人眼被人眼被视为纯白色。与这种白光谱相关的电力不仅分布在贡献波长上，而且在视觉角度上分布。对于许多应用，可用的光线需要在向前的方向上退出LED，即在小角度到垂直。在这项工作中，我们证明了白色LED顶部的专门设计的多层薄膜增加了向前发射的纯白光的功率。因此，推导的多目标优化问题是通过实质物理引导的目标函数重新重新制定，该函数代表了我们工程问题的层次结构。采用贝叶斯优化的变体基于射线跟踪模拟来最大化这种非确定性目标函数。最终，对合适的多层薄膜的光学性质的研究允许识别白光方向性的增加的机制：角度和波长选择性过滤导致多层薄膜与光线的乒乓球发挥作用。

This paper presents a construction of a proper and stable labelled sample compression scheme of size $O(\VCD^2)$ for any finite concept class, where $\VCD$ denotes the Vapnik-Chervonenkis Dimension. The construction is based on a well-known model of machine teaching, referred to as recursive teaching dimension. This substantially improves on the currently best known bound on the size of sample compression schemes (due to Moran and Yehudayoff), which is exponential in $\VCD$. The long-standing open question whether the smallest size of a sample compression scheme is in $O(\VCD)$ remains unresolved, but our results show that research on machine teaching is a promising avenue for the study of this open problem. As further evidence of the strong connections between machine teaching and sample compression, we prove that the model of no-clash teaching, introduced by Kirkpatrick et al., can be used to define a non-trivial lower bound on the size of stable sample compression schemes.

Unsupervised object discovery aims to localize objects in images, while removing the dependence on annotations required by most deep learning-based methods. To address this problem, we propose a fully unsupervised, bottom-up approach, for multiple objects discovery. The proposed approach is a two-stage framework. First, instances of object parts are segmented by using the intra-image similarity between self-supervised local features. The second step merges and filters the object parts to form complete object instances. The latter is performed by two CNN models that capture semantic information on objects from the entire dataset. We demonstrate that the pseudo-labels generated by our method provide a better precision-recall trade-off than existing single and multiple objects discovery methods. In particular, we provide state-of-the-art results for both unsupervised class-agnostic object detection and unsupervised image segmentation.

Social insects such as ants communicate via pheromones which allows them to coordinate their activity and solve complex tasks as a swarm, e.g. foraging for food. This behaviour was shaped through evolutionary processes. In computational models, self-coordination in swarms has been implemented using probabilistic or action rules to shape the decision of each agent and the collective behaviour. However, manual tuned decision rules may limit the behaviour of the swarm. In this work we investigate the emergence of self-coordination and communication in evolved swarms without defining any rule. We evolve a swarm of agents representing an ant colony. We use a genetic algorithm to optimize a spiking neural network (SNN) which serves as an artificial brain to control the behaviour of each agent. The goal of the colony is to find optimal ways to forage for food in the shortest amount of time. In the evolutionary phase, the ants are able to learn to collaborate by depositing pheromone near food piles and near the nest to guide its cohorts. The pheromone usage is not encoded into the network; instead, this behaviour is established through the optimization procedure. We observe that pheromone-based communication enables the ants to perform better in comparison to colonies where communication did not emerge. We assess the foraging performance by comparing the SNN based model to a rule based system. Our results show that the SNN based model can complete the foraging task more efficiently in a shorter time. Our approach illustrates that even in the absence of pre-defined rules, self coordination via pheromone emerges as a result of the network optimization. This work serves as a proof of concept for the possibility of creating complex applications utilizing SNNs as underlying architectures for multi-agent interactions where communication and self-coordination is desired.

Traffic forecasting has attracted widespread attention recently. In reality, traffic data usually contains missing values due to sensor or communication errors. The Spatio-temporal feature in traffic data brings more challenges for processing such missing values, for which the classic techniques (e.g., data imputations) are limited: 1) in temporal axis, the values can be randomly or consecutively missing; 2) in spatial axis, the missing values can happen on one single sensor or on multiple sensors simultaneously. Recent models powered by Graph Neural Networks achieved satisfying performance on traffic forecasting tasks. However, few of them are applicable to such a complex missing-value context. To this end, we propose GCN-M, a Graph Convolutional Network model with the ability to handle the complex missing values in the Spatio-temporal context. Particularly, we jointly model the missing value processing and traffic forecasting tasks, considering both local Spatio-temporal features and global historical patterns in an attention-based memory network. We propose as well a dynamic graph learning module based on the learned local-global features. The experimental results on real-life datasets show the reliability of our proposed method.

Motion prediction systems aim to capture the future behavior of traffic scenarios enabling autonomous vehicles to perform safe and efficient planning. The evolution of these scenarios is highly uncertain and depends on the interactions of agents with static and dynamic objects in the scene. GNN-based approaches have recently gained attention as they are well suited to naturally model these interactions. However, one of the main challenges that remains unexplored is how to address the complexity and opacity of these models in order to deal with the transparency requirements for autonomous driving systems, which includes aspects such as interpretability and explainability. In this work, we aim to improve the explainability of motion prediction systems by using different approaches. First, we propose a new Explainable Heterogeneous Graph-based Policy (XHGP) model based on an heterograph representation of the traffic scene and lane-graph traversals, which learns interaction behaviors using object-level and type-level attention. This learned attention provides information about the most important agents and interactions in the scene. Second, we explore this same idea with the explanations provided by GNNExplainer. Third, we apply counterfactual reasoning to provide explanations of selected individual scenarios by exploring the sensitivity of the trained model to changes made to the input data, i.e., masking some elements of the scene, modifying trajectories, and adding or removing dynamic agents. The explainability analysis provided in this paper is a first step towards more transparent and reliable motion prediction systems, important from the perspective of the user, developers and regulatory agencies. The code to reproduce this work is publicly available at https://github.com/sancarlim/Explainable-MP/tree/v1.1.

Ensuring safety is of paramount importance in physical human-robot interaction applications. This requires both an adherence to safety constraints defined on the system state, as well as guaranteeing compliant behaviour of the robot. If the underlying dynamical system is known exactly, the former can be addressed with the help of control barrier functions. Incorporation of elastic actuators in the robot's mechanical design can address the latter requirement. However, this elasticity can increase the complexity of the resulting system, leading to unmodeled dynamics, such that control barrier functions cannot directly ensure safety. In this paper, we mitigate this issue by learning the unknown dynamics using Gaussian process regression. By employing the model in a feedback linearizing control law, the safety conditions resulting from control barrier functions can be robustified to take into account model errors, while remaining feasible. In order enforce them on-line, we formulate the derived safety conditions in the form of a second-order cone program. We demonstrate our proposed approach with simulations on a two-degree of freedom planar robot with elastic joints.

Mitotic activity is a crucial proliferation biomarker for the diagnosis and prognosis of different types of cancers. Nevertheless, mitosis counting is a cumbersome process for pathologists, prone to low reproducibility, due to the large size of augmented biopsy slides, the low density of mitotic cells, and pattern heterogeneity. To improve reproducibility, deep learning methods have been proposed in the last years using convolutional neural networks. However, these methods have been hindered by the process of data labelling, which usually solely consist of the mitosis centroids. Therefore, current literature proposes complex algorithms with multiple stages to refine the labels at pixel level, and to reduce the number of false positives. In this work, we propose to avoid complex scenarios, and we perform the localization task in a weakly supervised manner, using only image-level labels on patches. The results obtained on the publicly available TUPAC16 dataset are competitive with state-of-the-art methods, using only one training phase. Our method achieves an F1-score of 0.729 and challenges the efficiency of previous methods, which required multiple stages and strong mitosis location information.

Given a set of points in the Euclidean space $\mathbb{R}^\ell$ with $\ell>1$, the pairwise distances between the points are determined by their spatial location and the metric $d$ that we endow $\mathbb{R}^\ell$ with. Hence, the distance $d(\mathbf x,\mathbf y)=\delta$ between two points is fixed by the choice of $\mathbf x$ and $\mathbf y$ and $d$. We study the related problem of fixing the value $\delta$, and the points $\mathbf x,\mathbf y$, and ask if there is a topological metric $d$ that computes the desired distance $\delta$. We demonstrate this problem to be solvable by constructing a metric to simultaneously give desired pairwise distances between up to $O(\sqrt\ell)$ many points in $\mathbb{R}^\ell$. We then introduce the notion of an $\varepsilon$-semimetric $\tilde{d}$ to formulate our main result: for all $\varepsilon>0$, for all $m\geq 1$, for any choice of $m$ points $\mathbf y_1,\ldots,\mathbf y_m\in\mathbb{R}^\ell$, and all chosen sets of values $\{\delta_{ij}\geq 0: 1\leq i<j\leq m\}$, there exists an $\varepsilon$-semimetric $\tilde{\delta}:\mathbb{R}^\ell\times \mathbb{R}^\ell\to\mathbb{R}$ such that $\tilde{d}(\mathbf y_i,\mathbf y_j)=\delta_{ij}$, i.e., the desired distances are accomplished, irrespectively of the topology that the Euclidean or other norms would induce. We showcase our results by using them to attack unsupervised learning algorithms, specifically $k$-Means and density-based (DBSCAN) clustering algorithms. These have manifold applications in artificial intelligence, and letting them run with externally provided distance measures constructed in the way as shown here, can make clustering algorithms produce results that are pre-determined and hence malleable. This demonstrates that the results of clustering algorithms may not generally be trustworthy, unless there is a standardized and fixed prescription to use a specific distance function.

当植物天然产物与药物共容纳时，就会发生药代动力学天然产物 - 药物相互作用（NPDIS）。了解NPDI的机制是防止不良事件的关键。我们构建了一个知识图框架NP-KG，作为迈向药代动力学NPDIS的计算发现的一步。 NP-KG是一个具有生物医学本体论，链接数据和科学文献的全文，由表型知识翻译框架和语义关系提取系统，SEMREP和集成网络和动态推理组成的构建的科学文献的全文。通过路径搜索和元路径发现对药代动力学绿茶和kratom-prug相互作用的案例研究评估NP-KG，以确定与地面真实数据相比的一致性和矛盾信息。完全集成的NP-KG由745,512个节点和7,249,576个边缘组成。 NP-KG的评估导致了一致（绿茶的38.98％，kratom的50％），矛盾（绿茶的15.25％，21.43％，Kratom的21.43％），同等和矛盾的（15.25％）（21.43％，21.43％，21.43％ kratom）信息。几种声称的NPDI的潜在药代动力学机制，包括绿茶 - 茶氧化烯，绿茶 - 纳多洛尔，Kratom-Midazolam，Kratom-Quetiapine和Kratom-Venlafaxine相互作用，与已出版的文献一致。 NP-KG是第一个将生物医学本体论与专注于天然产品的科学文献的全文相结合的公斤。我们证明了NP-KG在鉴定涉及酶，转运蛋白和药物的药代动力学相互作用的应用。我们设想NP-KG将有助于改善人机合作，以指导研究人员将来对药代动力学NPDIS进行研究。 NP-KG框架可在https://doi.org/10.5281/zenodo.6814507和https://github.com/sanyabt/np-kg上公开获得。